Immunology of type 1 diabetes

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Immunology of type 1 diabetes.

The incidence of type 1 diabetes in the UK is 20 per 100 000 and increasing, particularly in the under5-years age group. It comes with the burden of daily insulin injection and blood testing, as well as both shortand long-term complications, and this can include premature death. The standardized mortality ratio for type 1 diabetes has been estimated as 4-fold for females and 2.7-fold for males ...

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Immunology and genetics of type 1 diabetes.

Type 1 diabetes is one of the most well-characterized autoimmune diseases. Type 1 diabetes compromises an individual's insulin production through the autoimmune destruction of pancreatic beta-cells. Although much is understood about the mechanisms of this disease, multiple potential contributing factors are thought to play distinct parts in triggering type 1 diabetes. The immunological diagnosi...

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Type 1 diabetes: molecular, cellular and clinical immunology.

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Type 1 diabetes: etiology, immunology, and therapeutic strategies.

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We only know for sure that autoimmunity is the predominant effector mechanism of T1D, but may not be its primary cause. T1D precipitates in genetically susceptible individuals, very likely as a result of an environm...

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ژورنال

عنوان ژورنال: QJM: An International Journal of Medicine

سال: 2005

ISSN: 1460-2393,1460-2725

DOI: 10.1093/qjmed/hci088